Periprosthetic lipoma of the corpus callosum is an intracranial lipoma that grows in this one area of the corpus callosum. Lipoma of the corpus callosum is an abnormal embryonic development of the central nervous system, resulting in fat tissue, the tumor in the clinic usually does not have obvious clinical symptoms, is a kind of benign tumor. Generally speaking, lipoma grows in the midline of the brain, located in the contact area between the left brain and the right brain, which is a kind of congenital lipoma, and most of the lipomas are in a stable state in the process of follow-up, and will grow gradually with age. Therefore, when a lipoma of the corpus callosum is found in the clinic, we should pay attention to the follow-up observation by cranial CT or cranial magnetic resonance imaging, and if the lipoma gradually increases in size, it may lead to the appearance of corresponding clinical symptoms, and then undergo surgical resection if necessary. If the lipoma of the corpus callosum is found in the clinic, consult the neurosurgery department of the regular hospital to avoid delaying the condition.