Gabapentin capsules are currently recommended for the treatment of postherpetic neuralgia and diabetic peripheral neuralgia, and are also effective in other types of neuropathic pain, making it one of the first-line drugs used in pain medicine for the treatment of neuropathic pain. Since the use of gabapentin requires a gradual increase in dosage, many patients are not clear about it, and even if it is explained, sometimes it is still somewhat ambiguous. Therefore, it is hoped that this article will help patients to correctly grasp the use of gabapentin capsules in order to control pain as soon as possible. Note: 1. 1 capsule in the above table refers to the 300mg/capsule dosage form, which is the dosage form of gabapentin capsules used in the pain department of the China-Japan Friendship Hospital; at the same time, there are also 100mg/capsule dosage forms in China, so pay attention to the conversion relationship when using them. 2. The time of taking the medicine: generally there are no special strict rules, it can be taken before or after meals; however, it must be taken on time and regularly. 3. Not every patient must take the drug to the extent of 6 capsules per day. If you experience significant pain relief (relief greater than 75％) or intolerable side effects (mainly dizziness, nausea, unstable walking) at the time of 4 capsules/day, you do not need to continue to increase the drug and temporarily maintain it at the level of 4 capsules/day and observe it. 4. Whether the drug is increased or to be discontinued, it must be done gradually and never with a sudden increase or sudden decrease in dosage. There have been cases: the patient did not listen carefully to the doctor’s instructions, and took 1 capsule on the 1st day of taking the drug in the morning, in the middle of the day and in the evening, resulting in dizziness, tinnitus and vomiting. After resuming the normal order of taking the drug, the pain was obviously relieved and there were not as serious adverse reactions as before. In another patient, when reducing the medication, instead of gradually reducing it in order, he changed from 6 capsules/day to no longer taking it at once, which resulted in a recurrence and aggravation of pain, and after gradually reducing the medication in order, there was no significant recurrence of pain. 5. For elderly patients or patients with renal insufficiency, creatinine clearance needs to be calculated as a guide to the precise dosage of gabapentin. Patients can either retain all urine for 24 hours at the hospital and have the values calculated by the laboratory department, or measure weight and blood creatinine separately and estimate creatinine clearance in combination with gender and age. If patients are not comfortable with the first approach, they can send the following values (gender, age, weight, and most recent blood creatinine value) to Dr. Liu Botao’s studio, after which they will reply with the relevant creatinine clearance values and the recommended dose of gabapentin will be given.