Mastocytosis, whose incidence accounts for about 40% of women of childbearing age and 75% of all breast diseases, is the most common breast disease. The main clinical manifestations are varying degrees of stabbing pain, swelling, especially premenstrual pain, and postmenstrual pain, pain changes with mood swings, and can be radiated to the armpit and back of the shoulder. On examination, nodular, lumpy or striated masses can be palpated in the thickened breast glands, and a few patients have nipple overflow, often accompanied by chest tightness, irritability and menstrual irregularities. The main reason for its development is endocrine disorder. The disease can be cured clinically with timely and correct treatment, and the prognosis is generally good. However, because the disease is chronic and prone to recurrence, it must be treated according to a course of medication, usually a course of 1-3 months, and sometimes several courses of continuous treatment are needed to completely cure. Some patients often cannot take the medication according to the treatment course for various reasons, but only take the medication when they are in pain, and stop when they are not in pain, and so on repeatedly, and cannot achieve the purpose of treatment. In addition, the occurrence and recurrence of this disease is closely related to the human spirit and mood, so individuals should also maintain a good mental state, keep a relaxed mood, emotional stability, do not remember irritation and depression. Whether mastocytosis can become cancerous or not is the concern of many patients and is the focus of our long-term debate, which has not yet been unified. However, one thing has been recognized by experts and scholars at home and abroad, that is, the risk of atypical hyperplasia of the breast becoming cancerous is high, and it is regarded as a precancerous lesion. Therefore, it is most important for patients with mastocytosis to have regular checkups. Commonly used examination methods include high frequency mammography, ultrasonography, needle aspiration cytology, puncture biopsy, excisional biopsy and excisional biopsy. If the lumps do not shrink but increase in size and harden, if the nipples are overflowing with fluid or blood, if the mammogram cannot exclude cancer, or if there is one or more calcifications on the mammogram, especially small mud-like or needle-point-like calcifications, surgical biopsy should be performed to clarify the diagnosis, and do not delay the disease for fear of surgery.