How is the diagnosis confirmed? You need to come to the hospital for some relevant tests to draw blood and make a clear diagnosis. We will not go into details here. How to treat? In the acute and subacute phases of the disease, including the acute onset of the chronic phase, antibacterial therapy is the main treatment. (1) General treatment: bed rest, supply nutritious diet and sufficient amount of water; intravenous rehydration and antipyretic and analgesic agents can be given when the patient has high fever. (2) Antibacterial treatment: To improve the efficacy, prevent drug resistance and reduce recurrence, combined drugs are often used. As Brucella intracellularis ①Streptomycin, tetracycline combination therapy: streptomycin 0.5g, intramuscular injection, twice a day; tetracycline 0.5g, four times a day. The course of treatment is usually not less than 3 weeks, with an interval of 5-7 days, and 2-3 courses of treatment are appropriate. ②Streptomycin and doxycycline combination therapy: streptomycin 0.5g, twice daily, intramuscular injection for 2-3 weeks; doxycycline 0.2g daily, for 6 weeks. Foreign scholars believe that it is the more effective drug regimen. ③Kanamycin or gentamicin, tetracycline combination therapy: kanamycin 1.5g daily or gentamicin 240,000U, diluted and then intravenous; tetracycline 0.5g, 4 times daily, for 3 weeks. ④Rifampicin and doxycycline combination therapy: rifampicin 0.6-0.9g daily, doxycycline 0.2g daily, dose, course of treatment for 6 weeks, total 2 courses. Rifampin is a broad-spectrum antibiotic, which can easily penetrate the cell wall and has better efficacy and low recurrence rate. ⑤ Cotrimoxazole: 2 tablets each time, 3 times a day, 6 weeks of treatment. (3) Adrenocorticosteroids: Used for severe patients, such as severe toxemia, significant swelling of the testicles, serious lesions in the heart and brain or complete blood cell reduction, commonly used hydrocortisone 200-300mg/day, or dexamethasone 10-20mg/day, diluted and then intravenous, the course of treatment 3-5 days or according to the improvement of symptoms gradually reduce the amount of discontinuation. The chronic phase should be treated with a combination of antibacterial therapy and specific desensitization therapy. (1) Specific desensitization therapy: Bacterial vaccine, hydrolysin and lysozyme can be used, which is suitable for chronic joint disease and migratory lesions. (1) vaccine desensitization therapy: the general dosage for adults (for inactivation of Brucella) is 100,000/200,000, 200,000/300,000, 300,000/500,000, 500,000/1,000,000, 500,000/2,500,000, 500,000/5,000,000 bacteria, each fraction represents a daily amount, the numerator is the preparation amount, the denominator is the action amount, the first time to inject the preparation amount, the second time (1.5-2.0 hours after giving the preparation amount ). The interval between the two injections is 3 to 5 days, and 7 to 10 times is a course of treatment. The dosage can be increased one by one according to the reaction after injection, and it is appropriate that the body temperature fluctuates from 38 to 40℃ after static injection. This treatment can cause chills, high fever, sweating, joint pain and other severe reactions. It mostly starts 1 to 2 hours after injection, peaks at 8 to 12 hours, and lasts 12 to 24 hours for relief. Bacterial vaccination therapy should be combined with antibacterial drugs. Contraindicated in hepatic and renal insufficiency, cardiovascular disease, active tuberculosis, and pregnant women. (2) Hydrolysing and lysozyme desensitization therapy: The first dose is given daily: 1% 1ml, and then gradually increased to 2m1 according to the situation, 10 to 15 days as a course of treatment. (2) Antibacterial therapy: It is generally believed that streptomycin combined with tetracycline has certain efficacy, but the course of tetracycline should be extended to more than 6 weeks, and streptomycin to 4 weeks is appropriate. (3) Surgical treatment: Applicable to bacterial synovitis, arthritis, osteomyelitis, etc. For purulent lesions, surgical drainage can be performed. Osteomyelitis should be thoroughly debridement, supplemented by long-term antibacterial therapy, in addition to tetracycline primary streptomycin, or try the combination of chloramphenicol and gentamicin therapy. Spondylitis or intervertebral disc infection usually does not require surgical drainage. Treatment of Complications Treatment of comorbidities (1) Brucella meningitis: treatment should consider whether the drug crosses the blood-brain barrier. Chloramphenicol combined with streptomycin is more effective. Chloramphenicol should be given 2-3g daily as an IV for 2-3 weeks. (2) Brucella endocarditis: Combination of chloramphenicol, streptomycin, tetracycline and sulfonamide can be used for a long course of treatment. Rifampin combined with streptomycin can also be used for treatment. In addition to the disappearance of clinical symptoms, embolism, and repeated negative blood cultures, the significant decrease in IgG antibody potency often indicates complete clearance of the pathogenic bacteria