In the case of severe premature ejaculation, it is best to first go to the urological male department for treatment, and then take medication under the guidance of a professional physician, such as selective 5-hydroxytryptamine reuptake inhibitors, tricyclic antidepressants, etc. Local topical anesthetics and traditional Chinese medicine can also be used for treatment to avoid delaying the condition. 1. selective 5-hydroxytryptamine reuptake inhibitors: usually patients with severe premature ejaculation can take selective 5- The most common ones, such as dapoxetine, are effective in treating male premature ejaculation. The main purpose is to increase the content of 5-hydroxytryptamine neurotransmitters in the central nervous system, thus improving the control of ejaculation and prolonging sex; 2. Tricyclic antidepressants: such as chlorpromazine and sertraline, which are antidepressants used to treat premature ejaculation; 3. Topical anesthetics: before sex, topical anesthetics can be used at the glans, such as lidocaine and oxybutynin gel, to reduce sensitivity and prolong the time of ejaculation; 4. Chinese medicine: the symptoms of premature ejaculation, which are considered by Chinese medicine to be caused by deficiency of kidney essence, can be relieved by taking some Chinese medicines, such as Wuzi Yan Zong Wan, Locked Yang Solid Essence Pill, Ginseng Pill, Power Tonic Jin Qiu Capsule, Jin Shui Bao Tablet, Sheng Li Xiong Pill, etc. If patients have severe premature ejaculation, they can also opt for surgical treatment through dorsal penile nerve selective excision surgery, which is used to reduce penile sensitivity, and the efficacy of this surgery is still controversial. In daily life, premature ejaculation patients should quit the habit of masturbation, as well as relax, do more physical exercise and quit smoking and drinking, which also have a certain effect on premature ejaculation.