E2, estrogen receptor positive, progesterone receptor positive, BMI, living with grandparents, love of snacking, history of testicular lesions, and a family history of similar disease are high risk factors for gynecomastia. There is a significant correlation between increased body mass or obesity and GYN, the body mass of GYN patients is significantly higher than that of normal controls, up to 63% of GYN patients are obese, and the degree of development increases with obesity [9], obese patients with mastopathy also have more pronounced hormonal dysregulation, which may be due to the fact that obesity enhances adipose tissue aromatization and increases the conversion of testosterone to E2, resulting in increased blood This may be due to the fact that obesity enhances the aromatization of adipose tissue and increases the conversion of testosterone into E2, leading to an increase in the level of E2 in the blood, and obesity is more likely to produce insulin resistance (IR) and a decrease in insulin clearance.