In addition to joint and muscle symptoms, rheumatic diseases can cause multi-system and multi-organ damage, which can be life-threatening in serious cases. The following is a brief description of the damage caused by rheumatic diseases in each system: Circulatory system The heart and blood vessels are the main organs of the circulatory system. It can lead to blindness, disability and death. Common symptoms such as: chest tightness, palpitation, lip cyanosis, dyspnea, lower limb edema, claudication, limb gangrene, etc. Respiratory system Trachea, bronchus and lung tissue are the main organs of the respiratory system. Rheumatic diseases can invade trachea, bronchial cartilage, lung interstitium and lung parenchyma, resulting in tracheal chondritis, tracheal collapse, dyspnea, fine bronchitis,, interstitial pneumonia, pulmonary fibrosis, diffuse alveolar hemorrhage, etc. Common symptoms such as: cough, sputum, chest tightness, dyspnea, hemoptysis, fever, pleural effusion, etc. Digestive system Esophagus, stomach, intestine, liver and bile are the main organs of the digestive system. Rheumatic diseases can invade the muscular layer of esophageal wall and esophageal mucosa, gastrointestinal smooth muscle and mucosa, liver tissue and bile duct, resulting in abnormal esophageal peristalsis, dysphagia, upper gastrointestinal bleeding, biliary cirrhosis and portal hypertension. Common symptoms such as abdominal pain, diarrhea, vomiting, black stool, vomiting blood, jaundice, ascites, difficulty in eating, etc. Urinary system The kidney is the main organ of the urinary system. Rheumatic diseases can invade the renal interstitium and renal parenchyma, leading to interstitial nephritis, glomerulonephritis, glomerulosclerosis, acute and chronic renal failure, etc. Common symptoms such as edema, oliguria, anuria, back pain, etc. Blood system Blood cells are one of the main components of blood. Rheumatic diseases can damage blood cells through various ways, resulting in anemia, thrombocytopenia, granulocyte deficiency, etc. At the same time, a variety of auto-antibodies, such as rheumatoid factor, anti-“O”, anti-cardiolipin antibodies, anti-nuclear antibodies, anti-ds-D N A These autoantibodies are an important basis for the diagnosis of rheumatic diseases. Common symptoms include dizziness, fatigue, bleeding, palpitations, and susceptibility to infection. Nervous system The brain, spinal cord and peripheral nerves are the main components of the nervous system. Rheumatic diseases can invade central and peripheral nerves, leading to mental abnormalities, cerebral hemorrhage, cerebral embolism, cerebral thrombosis, encephalitis, disc herniation, spinal stenosis and peripheral neuritis. Common symptoms such as: mental confusion, abnormal behavior, unexplained fever, coma, stroke, hemiplegia, back and leg pain, numbness and pain in the limbs, burning and ankylosing sensation.