The mucosa is one of the tissues in the body that covers the lumen of the respiratory and digestive tracts and other organs and plays a protective role; while chronic inflammation of the mucosa is a pathological description that indicates inflammation of the mucosa in a part of the body, commonly found in the esophagus, gastrointestinal tract, and cervix, with different symptoms. Chronic inflammation of the mucosa can be detected by pathological biopsy, where cellular infiltration can be seen; this pathology is usually the result of long-term effects of physical wear and tear, chemical irritation, and infection, resulting in a chronic inflammatory response of the body’s mucosa, which, if there are no specific symptoms, is basically free of malignant tendencies and can recover on its own by improving lifestyle. If the stimulation is more serious, there will be some clinical manifestations, commonly developing in the gastrointestinal tract and cervical area, such as abdominal pain, decreased appetite, abnormal vaginal discharge, etc., which require timely medical examination and treatment. It is recommended that both patients and ordinary people should usually pay attention to good living and eating habits, such as eating less spicy and stimulating, too hot, too cold, too hard food, etc., to avoid all kinds of adverse stimuli triggering chronic inflammation of the mucous membrane.