Foliar depigmentation is most commonly seen in tuberous sclerosis and is one of its clinical manifestations as an oval, striated, lobe-shaped hypopigmented spot. The disease is autosomal dominant, and disseminated cases are also common. The gene is localized at 9q34 or 16q13.3, a tumor suppressor gene, and the gene products are hamartin and tuberin, respectively, both of which regulate cell growth. What tests are required for lobar depigmentation? Diagnostic tests for lobar depigmentation: 1. Skin changes: mainly sebaceous adenoma of the face. 2. Neurological symptoms and signs: manifested as epilepsy and mental retardation. 3.Ocular changes: most commonly optic papillae and retinal nodules. Diagnosis: The diagnosis of sebaceous adenoma, mental retardation and epilepsy can be confirmed by the presence of the three main signs. However, the three main signs do not always appear together in clinical practice. Sebaceous adenoma is seen in almost all patients; fundus lesions are often found during ophthalmologic consultations after the diagnosis of sebaceous adenoma is confirmed.