The pathogenesis is still not clear.
The possible etiologies are.
I. Infectious factors
II. Genetic factors
Immune factors
IV. Psychological factors
I. Infectious factors pathogenic microorganisms are non-specific promoters of infectious factors.
※ Intestinal inflammation often occurs in areas with high bacterial density.
Some bacterial proteins are similar in molecular structure to human proteins and can induce autoimmune reactions.
※ Enteritis cannot be induced in experimental animals under sterile conditions.
The incidence of genetic factors varies significantly among races and blood relatives.
High family incidence, with a family history of approximately 30%.
A higher incidence in monozygotic twins than in dizygotic twins.
High incidence of first-degree relatives.
Racial differences: Caucasian prevalence > Black prevalence.
Immunogenic factors promote the disease in susceptible individuals and stimulate a hyperactive immune response in the intestinal mucosa.
The main basis for the pathogenesis of immune factors.
※ Often associated with other autoimmune diseases: arthritis.
※ Anti-autoantibodies: anti-colonic epithelial cell antibodies.
Abnormal changes in T-lymphocytes.
Abnormal changes in immunoglobulins.
The disease is triggered by stress and exertion, and patients often show depression and anxiety. Psychological factors are often the triggering or aggravating factors of the disease.