After cryotherapy, if no local breakage is formed, appropriate contact with water is possible. Cryotherapy is the use of lesion tissue contact with low temperature after the occurrence of local blood circulation disorders, protein denaturation, as well as tissue cell necrosis, shedding, so as to achieve the purpose of removing local tissue. Refrigerants mainly include liquid nitrogen, carbon dioxide and other substances. After freezing, local vascular tissue contraction, visible instant white, late local swelling to form blisters and other symptoms, if the local does not break, at this time can be appropriate contact with water. However, if the blisters break down later, contact with water will increase the risk of infection, and it is also not recommended to touch water while the wound is still healing. Cryotherapy is indicated for various viral warts, keloids, superficial benign tumors, and septic granulomas, but there are certain adverse effects, mainly secondary infections and pain.