Patients with perforated eardrums and suppuration are generally diagnosed with acute suppurative otitis media, which is often caused by bacterial infection. Clinically, patients can consider using levofloxacin ear drops to reduce inflammation. Before using the medication, it is necessary to use hydrogen peroxide and saline to clean out the pus inside the ear, which can effectively allow the medication to contact with the mucous membrane of the ear canal and reduce inflammation, while patients need to take oral cephalosporin antibiotics to reduce inflammation, commonly used is cefdinir dispersible tablets, and it is necessary to clarify whether there is any allergy history before using the medication. If the patient’s eardrum perforation does not heal after active systemic treatment, surgical repair needs to be considered.