1. Genetic factors A study led and directed by Dr. Claus from the Department of Infectious Diseases and Public Health at Yale University School of Medicine confirmed that women with mutations in the BRCA1 or BRCA2 genes will have a 7-fold increased risk of breast cancer. This reveals the significance of genetic factors for breast cancer. Further studies have confirmed that women in families with a first-degree direct family history of breast cancer have a two to three times higher risk of breast cancer than the normal population. When there is a history of breast cancer in the family, it is important to focus on regular medical checkups and self-examinations. Environmental factors A retrospective analysis by the Cold Spring Harbor Institute in the United States showed that there are 216 compounds associated with breast cancer in substances that women are frequently exposed to in their daily lives, and 29 of these potentially carcinogenic substances are produced in large quantities in the United States every year, with a production of more than 500,000 kg of compounds. These compounds are widely distributed among household products such as pesticides, cosmetics, gasoline, pharmaceuticals, and everyday products, including benzene in automotive pollutants, acrylamide formed when starchy foods are processed at high temperatures (such as French fries), perfluorooctanoic acid used in furniture or kitchenware, and polyvinyl fluoride used in the manufacture of artificial leather. Because of this, researchers believe that women in developed countries have a more than five times higher risk of breast cancer compared to women in developing countries, and that environmental factors cannot be ignored. Moreover, the results of genetic studies on twins show that environmental factors are associated with the development of most breast cancers – to a large extent influencing the timing of the onset of breast cancer. Recall the report about Chen Xiaoxu: “Because the marble is radioactive and Chen lived in it for years and years, her body was exposed to radiation for a long time, which eventually stimulated a deficiency of suppressor cells and directly led to an overgrowth of heterogeneous growth cells and the formation of breast cancer, a tumor of the endocrine system. ” It cannot be said that Chen Xiaoxu’s breast cancer must be the result of long-term radiation of radioactive material inside the marble, but long-term radiation will definitely promote the formation of breast cancer. 3, personal life experience, habits also play a pivotal role. Some women use estrogen to delay menopause in order to “prolong their youth”; some women use cosmetics containing estrogen for a long time for cosmetic purposes; and estrogen is widely used for replacement therapy in the treatment of menopausal syndrome…. …All these initiatives may disrupt the normal hormone levels in the body, which then become an important factor in breast cancer. It can be seen that hormonal imbalance in women is a high risk factor for breast cancer, which has been confirmed by many clinical data. Medical experts have long found that the incidence of breast cancer among women increases with age, especially after menopause, and reaches its peak around the age of 70, one of the important reasons is the hormonal imbalance brought about by age, especially menopause. Moreover, statistics show that the risk of menarche is higher for those whose age of menarche is earlier than 13 years old than for women whose age of delivery is before 35 years old; oral contraceptives increase the risk of breast cancer …… These are all inextricably linked to the hormonal imbalance in the body. In addition, other bad habits can also increase the risk of breast cancer. 5. Women who drink heavily are more likely to develop breast cancer. Researchers from the American Epidemiological Association, through a survey of 62,000 menopausal women, claimed that excessive obesity is closely linked to the incidence of breast cancer. The study showed that women who gained 10 to 15 kilograms after the age of 18 and did not receive hormone replacement therapy had a 40 percent higher breast cancer rate than women who gained only 2 kilograms, and those who gained 30 kilograms would double their chances of developing the disease. According to the study, the main reason why obesity increases the chance of breast cancer is that excessive fat accumulation in the body leads to an increase in estrogen, which is stored in the fatty tissues after being lipidated and released into the bloodstream, stimulating the breast tissue and causing breast cancer over time. Experts suggest that it is important to pay attention to diet and maintain a healthy body, especially for menopausal women, which is a good way to reduce the chance of breast cancer. Johns Hopkins School of Public Health Hopkins School of Public Health researchers have studied 2,017 study subjects to determine whether depression and cancer are related in a trial that lasted 13 years. The results of the study found that patients with major depression were more likely to develop breast cancer compared to other women. Another study showed that people are under more pressure in modern society, and many women are often in a bad mental state such as depression and frustration, which becomes a major cause of breast cancer – clinical data shows that more than 80% of women with depression suffer from different degrees of breast disease, and that depressed people are five times more likely to develop breast cancer. The likelihood of breast cancer in depressed people is five times higher than that of normal people. The current trend of younger incidence among Chinese women is not unrelated to the high pressure of life, improved standard of living, fewer births and improved early diagnosis, I speculate.