The patient is a male, 75 years old, suffering from Parkinson’s for almost 6 years. Since the end of last year, he has been experiencing frequent urination at night, having to get up 6-7 times a night to urinate, and the total amount is also about 1000-1500 ML. The prostate and ureter were examined and everything was normal. I have seen a Chinese medicine doctor and took Chinese medicine for a month and a half, but it was not effective. 1. it is best to go to what hospital what department to check; 2. can you give some advice on treatment? As the saying goes, “Children sleep a lot and old people urinate a lot.” Increased nocturnal urination in the elderly is not a normal physiological phenomenon, much less a physiological need, but a potentially pathological manifestation of a common but under-recognized disease in life. There is no widely agreed definition, and the more common ones are as follows: 1. nocturnal urine production exceeds 35% of 24-hour urine production 2. nocturnal urine production > (number of hours of sleep/24)*24-hour urine production 3. nocturnal urine production exceeds 6.4 ml/kg, or exceeds 1/3 of total daytime total urine production,nocturnal urine production > 0.9 ml/min nocturnal urine production is attributed to nocturnal urine production exceeding maximum bladder capacity. There are the following reasons: A. Increased nocturnal urine production B. Decrease in bladder capacity C. Both of the first two points. A: The causes of increased nocturnal urine production are: Antidiuretic hormone (also called vasopressin) is a 9-peptide hormone secreted by the hypothalamus, whose main function is to increase the permeability of the distal convoluted tubules and collecting ducts to water, promote water absorption, and is a key regulatory hormone for urine concentration and dilution. In normal people, the secretion of antidiuretic hormone has a clear rhythm between day and night, which shows that the amount of secretion is significantly more at night than during the day, thus reducing the amount of urine at night and not disturbing sleep. In elderly people, the decrease in secretion of antidiuretic hormone and the lack of circadian rhythm are the endocrine causes of nocturia. In congestive heart failure, secretion of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) increases, and the physiological effects of ANP and BNP are to dilate blood vessels and increase sodium excretion, leading to increased urination. The increase in atrial natriuretic peptide leads to an increase in renal natriuretic drainage. If nocturia is suspected to have obstructive sleep apnea syndrome (what we usually call “snoring”), a polyphasic sleep recording survey can be done. Prostate enlargement, bladder dysfunction causing prolonged urinary tract obstruction, damage to the renal medulla and distal tubules, interference with normal urinary sodium excretion, resulting in water and sodium retention, leading to increased nocturnal urine production. Congestive heart failure and distal venous stasis disorders. Increased fluid in the third interstitial space (peritoneal, thoracic, synovial, cerebrospinal fluid, pericardial fluid) causes increased nocturnal urination. Patients with nocturnal polyuria in cardiac disease should have a careful history. Other causes: diabetes mellitus; uremia; excessive fluid intake (especially at night); diuretics taken at night; excessive salt intake; hypoalbuminemia; renal disease, etc. B: The causes of decreased bladder capacity are: 1 lower urinary tract obstruction 2 spontaneous nocturnal bladder forceps instability, neurogenic bladder 3 cystitis: bacterial interstitial tuberculosis radiological 4 tumors: bladder prostate urethral tumors 5 voiding dysfunction: xanthines (theophylline, caffeine), pharmacological effects of beta-blockers, stones (bladder stones, urinary tract stones). Emotional anxiety induced urinary dysfunction. At present, according to the medical history you provided, it is not possible to interpret what causes the increase in nocturia. I hope you can provide more test results and related medical history to help me judge your disease.