Pain Some people call it the 5th vital sign in addition to breathing, pulse, temperature and blood pressure, and it has its own unique role for the human body that is “warning”, or even “protection”. It alerts you to the need to seek medical attention as soon as possible. Chronic pain is pain that lasts more than one month. Some people have compared chronic pain to an undead cancer, and chronic pain not only causes physical damage, but also affects sleep, motor function, relationships and productivity. But, did you know? Depression and chronic pain often go hand in hand and need to be taken seriously; depression can accompany or exacerbate pain. Pain sites are variable or diverse. Headache, low back pain, extremity pain, chest pain …… Exaggerated pain levels or pain that is more constant and persistent. Easily accompanied by sleep disturbance, decreased appetite, and fatigue. Feeling more unable to control life. Often seek treatment from many sources with poor results, visit many famous doctors, the result is that I was poisoned by depression! Be careful! This may be due to a state of negative depression: abnormalities in the production and inhibition of pain sensations within the body. In turn, chronic pain can cause or exacerbate depression. Like this there is nothing to say, watch out for the unlucky ghost of depression again! 1. chronic anxiety 2. confused thinking 3. fatigue Irritability There is a “nocturnal pain”, pain may be aggravated at rest or at night, especially in cancer patients! How should depression combined with chronic pain be treated aggressively? SNRI drugs are the first choice for medication. SNRIs are effective for depression with pain due to their unique reuptake inhibition of norepinephrine (NE). For pain symptoms, it can be combined with other analgesic drugs or nerve blocks, etc. For depression symptoms, it can be combined with psycho-cognitive therapy, physical therapy, etc.