Fire cupping is a clinical treatment in Chinese medicine to prevent and treat diseases by means of local negative pressure and warmth coverage. During the treatment process, leaving the cupping jar for too long or having too much negative pressure inside the jar may cause local skin tissue hypoxia and ischemia, resulting in local skin blisters. In addition to this, the patient’s physical condition and errors in operation may also cause blisters to appear after cupping. Patients with sensitive skin, excessive dampness in the body, poor local blood circulation, and weak constitution are more likely to develop blisters during cupping, and it is recommended that patients with these conditions should reduce the retention time or not retain the cupping and use flash cupping. When cupping, if the cupping is not done properly, such as alcohol rubbing against the mouth of the bottle or unburned combustion materials, it may also burn the patient’s skin and cause blisters. Therefore, it is recommended that patients go to a regular hospital for cupping treatment, which has standard requirements for the operation and can avoid such situations to the maximum extent possible. If a patient develops blisters during cupping, small blisters usually do not need to be treated, but only need to be careful not to get infected and can absorb on their own with time. If the blister is too large, it is recommended that the patient be treated in a hospital, disinfected and can be coated with topical antibiotics to prevent infection.