In recent years, domestic and foreign research has found that more than 50 kinds of drugs that have adverse effects on sexual function, and therefore are attracting more and more attention. Hypotensive drugs These drugs are most closely related to sexual dysfunction such as loss of libido, loss of orgasm and impotence. For example, if the daily dosage of guanethidine is above 25 mg, most male patients will experience impotence, delayed ejaculation or inability to ejaculate; female patients have insufficient vaginal lubrication and decreased sexual desire. Therefore, the drug should not be used for newlyweds or husbands who are preparing their wives for conception. Although the daily dosage of methyldopa is less than 1 gram, some male patients may still experience decreased libido or impotence; female patients may also experience amenorrhea, overflow of breast milk, decreased sexual excitement and loss of orgasm. Even if the dose of Risperdal is small, it can also reduce libido, impotence, or inability to ejaculate in most male patients, and even induce depression, making the existing sexual dysfunction and low libido even more serious, so patients with a history of depression should not use Risperdal. Colistin can cause decreased libido or impotence in some male patients. Hydralazine when the daily dosage exceeds 200 mg, some male patients will have reduced libido and impotence. Mecamylamine has an inhibitory effect on the parasympathetic nerve, causing impotence in men; delayed or lack of orgasm in women. Prazosin reduces libido in some men; insufficient vaginal lubrication in women, affecting orgasm onset. Anti-cardiac drugs Digitalis, digoxin, and strong mind used for congestive heart failure can cause hypogonadism or impotence in men. The treatment of cardiac rhythm disorders of the heart, the daily dosage increased to 40-320 mg, is very easy to have a reduced libido and impotence. Diuretics Antiseptic has anti-androgenic effect, if used for a long time, it can cause hypogonadism or impotence in men; women can have irregular menstruation, amenorrhea, and even stop ovulation. Dihydrocortisone can cause impotence. Tachyphylaxis and diuretics can induce impotence due to hypokalemia, but it can be changed with potassium salt supplementation. Anticancer drugs Bactrim can induce testicular atrophy in men and amenorrhea in women. Cyclophosphamide can cause sperm and semen deficiency in men, especially when the dosage reaches 6 to 10 grams; it can also cause amenorrhea or menstrual irregularities in women. Methotrexate can cause semen deficiency. Colchicine can incur sperm deficiency. Antipsychotics Chlorpromazine at a daily dosage of up to 400 mg can reduce libido and impotence in male patients and shrink testicles with prolonged use; female patients are prone to hypersexuality or lack of libido. Lithium carbonate can make some male patients unable to ejaculate or develop impotence. Haloperidol is prone to impotence in male patients with long-term application; female patients are prone to menstrual irregularities and lack of libido. Methiodiazine can cause impotence or amenorrhea with long-term use. Sedative-hypnotic drugs Sedatives such as Valium and Advil can reduce libido and cause impotence if taken for a long time. Hypnotics such as luminal, amytal and tachyphylaxis can cause decreased libido, impotence or loss of orgasm in male patients when used for a long time. Hormones Estradiol and ethinyl estradiol, when used for men with prostate cancer, can cause a rapid decrease or loss of libido and lead to impotence and impaired ejaculatory function. Chlormadinone can cause decreased libido, impotence, or reduced orgasm in men. If a large amount of methyltestosterone and testosterone propionate is applied for a long time, it can cause testicular atrophy, reduce sperm and semen, and affect libido. Prednisone at a daily dose of 30 mg can affect spermatogenesis. Hydrogenated prednisone can cause semen deficiency. Thyroid powder can cause women to stop ovulating. Sulfonamides Sulfasalazine can cause semen deficiency and sperm reduction. Gastrointestinal antispasmodics Atropine sulfate, scopolamine (654-2) and prudensine can cause impotence in male patients; reduced sexual arousal in female patients. Anti-allergic drugs such as paracetamol, ankylin and finasteride can reduce sexual function in men and women. In addition, Antan, dysentery, anti-inflammatory pain, gastrofacial, eugenol and cimetidine, promethazine, etc., can also cause male and female sexual dysfunction. However, after 3 to 6 months of discontinuation, they can disappear on their own and gradually return to normal.