Chronic hepatitis C is difficult to treat once it has progressed to cirrhosis! Because the main drugs of hepatitis C antiviral therapy, interferon and ribavirin, both aggravate liver function damage in patients with cirrhosis, and their side effects can be more pronounced, making it difficult for patients to complete the course of treatment. Therefore, the treatment of hepatitis C cirrhosis must be developed under careful and systematic observation and conditioning by doctors combined with the current international and domestic evidence-based medical information on all aspects of hepatitis C treatment from Chinese and Western medicine. The following are some of our recommendations for the treatment of hepatitis C cirrhosis: 1, a comprehensive assessment of the nutritional status of patients with hepatitis C cirrhosis, liver function reserves, hepatitis C virus content and genotype, other co-morbidities and complications, etc., to exclude contraindications; 2, without cirrhosis ascites and jaundice, can be carefully observed under small doses with ordinary interferon once a day intramuscular injection (1-3 million), after 3 days if there is no significant If there is no significant discomfort after 3 days, add ribavirin 600mg/day, after a week interferon increases to 5 million and ribavirin to 800mg/day; after 4 weeks the standard treatment regimen can be changed to long-acting interferon + ribavirin 800-1200mg/day. If not tolerated during the treatment, return to the previous phase of the regimen. 3, patients with cirrhotic ascites, jaundice or upper gastrointestinal bleeding with decompensated cirrhosis must promptly control the above conditions is cirrhosis recovered to grade A before continuing treatment according to item 2. But because the existence of hepatitis C virus damage often makes the general liver care treatment is ineffective, so all international and domestic hepatitis C guidelines point out: decompensated hepatitis C cirrhosis first consider liver transplantation; this is basically a “death sentence” for most patients with hepatitis C cirrhosis. However, hepatologists have not given up, and have searched and tested various methods to control the progression of the disease. Such as interferon or with ribavirin in small doses for long-term application; bitter ginseng with immunomodulators such as thymidine; fluvastatin with vitamin D, etc., but the most successful is the bone marrow mesenchymal stem cell transplantation with hepatitis C cellular immune reconstitution therapy program, not only can quickly improve all aspects of liver function, control ascites, improve albumin levels, while improving the overall quality of the body, effective control of hepatitis C virus and make It also lays a good foundation for the standard interferon treatment program, thus curing hepatitis C.