Chronic atrophic gastritis with moderate enterosis is a type of gastritis. Chronic atrophic gastritis with enterosis is associated with further heterogeneous hyperplasia and, in severe cases, a high degree of intraepithelial neoplasia, leading to the development of early gastric cancer. There are many reasons for chronic atrophic gastritis with enterosis, the most common being H. pylori infection. Long-term H. pylori infection can lead to chronic inflammation of the mucosa, mucosal bleeding and edema with erosion, which can lead to gastric mucosal atrophy and subsequent enterosis over a long period of time. When there is intestinalization, it is necessary to clarify whether there is HP infection, and H. pylori positive is usually treated with quadruple therapy, a two-week course of anti-H. pylori treatment. Atrophic gastritis with moderate intestinalization is usually not reversible, so regular gastroscopy is needed to observe whether the intestinalization will progress further and whether the degree of atrophy will worsen, and if necessary, gastroscopic magnification and precise biopsy can be performed to rule out early gastric cancer.