Otitis media pus may be caused by acute and chronic suppurative otitis media, which can be treated with drugs such as amoxicillin and cefazolin. Suppurative otitis media can be acute and chronic, and need to be treated with medication according to the actual situation. For acute and chronic suppurative otitis media, patients need to use penicillin drugs such as amoxicillin and cephalosporin drugs such as cefazolin and cefradine as early as possible under the guidance of a doctor, and early treatment can prevent tympanic membrane perforation. If tympanic membrane perforation is needed, use 3% hydrogen peroxide solution to thoroughly clean and swab the pus from the external auditory canal, local antibiotic solution ear drops (0.3% ofloxacin, cotrimoxazole, rifampicin solution), after the inflammation subsides, use 3%~4% boric acid glycerin and other glycerol or ethanol preparations to drop the ear, the infection is completely controlled and the inflammation subsides completely, the tympanic membrane perforation of some patients can be healed on its own. It is recommended that patients with otitis media pus should consult a doctor in a timely manner to clarify the cause, targeted treatment under the guidance of the doctor to avoid deterioration of the condition.