Seronegative spondyloarthropathies is a general term for a group of diseases that are seronegative for rheumatoid factor and have spondyloarthropathy involvement. This group includes ankylosing spondylitis, Ritter syndrome, psoriatic arthritis, and enteropathic arthropathy. The reason for grouping these diseases together is that they have many clinical commonalities, such as a negative serum rheumatoid factor and a spine (including sacroiliac joints) as the main site of involvement. In order to distinguish it from some arthropathies that are serum rheumatoid factor positive and mainly involve the spinal joints, such as rheumatoid arthritis, the clinical name of seronegative spondyloarthropathy has been proposed. Clinical manifestations Typical asymmetric peripheral arthritis, mainly involving the joints of the lower extremities, arthritis tends to involve the medial joints, manifesting as spondylitis, sacroiliac arthritis, inflammation of the attachment points of the tendon ligament fascia and bone joints, manifesting as heel pain palmar pain. Serum rheumatoid factor is generally negative. There is also a variable tendency for familial aggregation associated with HLA-B27. Extra-articular manifestations often overlap with each other, such as psoriatic arthritis, Wright syndrome or enteropathic arthritis, except that patients may all have uveitis. Diagnosis European Spondyloarthropathy Study Group (ESSG) diagnostic criteria: inflammatory spondylodynia or synovitis (asymmetric or lower extremity predominant) + one of seven or more of the following: alternating hip pain; sacroiliac arthritis; attachment point disease; positive family history; psoriasis; inflammatory bowel disease; presence of Acute urethritis or cervicitis or acute diarrhea within 1 month prior to arthritis. Usually, attention should be paid to the correct posture of standing, sitting and lying to adhere to the spinal thoracic hip joint activities, it is advisable to sleep on a hard bed, low pillow, avoid excessive weight bearing, strenuous exercise. The main types of exercises included in the recovery program: (1) exercises to maintain the mobility of the thorax, such as deep breathing chest expansion exercises; (2) exercises to maintain the flexibility of the spine, such as the rotation of all aspects of the neck and waist movement; (3) physical exercises, such as walking push-ups and other swimming. Surgical open surgery is considered for advanced stages of hip stiffness and severe common spinal deformities, commonly known as total hip replacement and spinal osteotomy. Classification This is a group of diseases with negative blood rheumatoid factor, including Ankylosing spondylitis, Psoriatic arthropathy, Reiter’s syndrome, inflammatory bowel disease ( Inflammatory bowel disease), Reactive arthritis, Undifferentiated spondyloarthropathy, which are characterized by sacroiliitis, and These diseases are characterized by sacroiliitis, spondylitis, peripheral arthropathy, enthesopathy, and other extra-articular manifestations such as uveitis or conjunctivitis of the eyes, inflammation of the gastrointestinal or genitourinary tract, dry skin, and in a few patients, heart block or valve abnormalities, pulmonary fibrosis, IgA nephropathy), and various diseases are associated to varying degrees with the HLA-B27 gene.