Assessment of sleep in patients before and after temporal lobe epilepsy surgery

  A study conducted by Serafini et al. at the Gui de Chauliac Hospital in France evaluated the effects of epilepsy surgical treatment on sleep and published the results in a recent issue of Seizure. Eleven patients with refractory medial temporal lobe epilepsy, all surgically treated and seizure-free, were included in the study. Patients were monitored with 24-hour video EEG before surgery and at 1- and 2-year postoperative follow-up to assess interictal abnormal epileptiform discharges (IEA) and sleep structure parameters.  The results revealed that IEA decreased in all patients after surgery; total sleep and fast-acting eye sleep time increased significantly at the 1-year postoperative follow-up (P=0.032, P=0.006); fast-acting eye sleep time also increased significantly at the 2-year follow-up (P=0.028); and most of the significant changes occurred at the 1-year postoperative period.  The study suggests that surgical treatment of temporal lobe epilepsy improves sleep architecture by reducing the number of seizures and abnormal interictal discharges, and these results indirectly confirm that epilepsy can disrupt sleep architecture in the long term.