Clinically used uric acid-lowering drugs mainly include those that inhibit uric acid production and those that promote uric acid excretion, and when a single drug is not effective, two drugs are often used in combination. Alkaline drugs can also be used to reduce uric acid in the body by alkalizing the urine so that uric acid is less likely to accumulate. In addition, uric acid oxidase can break down uric acid into soluble products for discharge, which can also achieve the effect of lowering uric acid: I. Inhibition of uric acid production: 1. Allopurinol: This drug is suitable for patients who have excessive uric acid production in the body, or who are not suitable for the use of uric acid excreting drugs, but patients with renal insufficiency need to use discretion. A small number of patients may experience abdominal pain, diarrhea, rash, fever and other adverse reactions after use. 2. Febuxostat: This drug is indicated for those with mild to moderate renal insufficiency, and should be used with caution for those with severe renal insufficiency. It may cause abnormal liver function, diarrhea and other adverse reactions. 2. Promote uric acid excretion: 1. Benzbromarone: This drug is not suitable for patients with uric acid kidney stones. Adverse reactions include gastrointestinal symptoms, rash, renal colic, granulocytopenia, etc.; 2. Probenecid: Sulfasalazine allergy is prohibited. Third, alkaline drugs: such as sodium bicarbonate, but long-term use in large quantities may lead to the occurrence of adverse reactions such as metabolic alkalosis. Four, uric acid oxidase: commonly used are Lablase, Precautions, etc., through the decomposition of uric acid, so that it becomes soluble products excreted, and then to achieve the purpose of lowering uric acid. Since there are certain contraindications to the use of drugs and more or less some adverse reactions, they should be taken under the guidance and monitoring of a doctor. Patients can also drink moderate amount of water in daily life to promote the excretion of uric acid, and should avoid drinking alcohol, eating high purine food, etc.