Patient: Hospital surgery to replace mitral valve, repair tricuspid valve and build two bridges, recovered well after surgery. In May this year, he developed atrial fibrillation, irregular heart rate, and occasional chest tightness. The patient’s heart rate is uneven and he has occasional chest tightness. 1. he was treated at the local county hospital with amiodarone, amisulpride and warfarin for more than a month without effect. 2. he is now taking oral warfarin, spironolactone, pannamides and betalactam. Ultrasound ultrasound suggests: post mitral valve replacement: mild enlargement of left atrium, senile aortic valve degeneration. 4. June 9 ECG: odorous heart rate, atrial fibrillation. 1. Is it necessary to take medication all year round? 2. How should it be treated? 3. Does taking medication affect the eyes? Liu Bing, Department of Cardiology, Beijing Hospital, Ministry of Health: About 30-40% of patients will have combined atrial fibrillation after valve replacement or bypass surgery. It is not recommended to take amiodarone for a long time, because the side effects are many and serious (abnormal thyroid function, interstitial lung fibrosis, corneal pigmentation, etc.); it is enough to take betalactone to control the ventricular rate to reach the standard, and you also have coronary heart disease, and statin drugs need to be taken for a long time. Your atrial enlargement is not obvious yet, you can consider radiofrequency ablation, which can make 70-80% atrial fibrillation can be eradicated.