Clinical routine use of drugs for the treatment of heart failure are diuretics, angiotensin-converting enzyme inhibitors, β-blockers, digitalis drugs and other drugs. 1. Diuretics, the body fluid retention of patients, preferred to furosemide as the representative of the high efficiency diuretics; mild fluid retention and hypertension and no kidney damage in heart failure patients, available thiazide diuretics, but gout is contraindicated. 2. Angiotensin receptor enkephalinase dual inhibitors (ARNI)/angiotensin-converting enzyme inhibitors (ACEI)/angiotensin 2 receptor antagonists (ARB), such as sacubitril valsartan. 3. Aldosterone receptor antagonists, such as spironolactone can antagonize the effect of aldosterone on sodium retention, thus exerting diuretic and blood pressure-lowering effects. 4. β-blockers, such as metoprolol, can positively improve the patient’s cardiac functional status and improve the quality of survival. 5. digitalis drugs, through multiple pathways to improve myocardial contractile function and increase cardiac output, play an important role in the treatment of heart failure, such as digoxin. 6. Other drugs, such as griseofulvin, can effectively prevent the progression of atherosclerosis, reduce blood pressure and uric acid level, but also improve the deterioration of diabetic heart failure patients and reduce the rate of sudden death, so that patients with diabetes mellitus combined with heart failure benefit; the most novel drug is the soluble guanylate cyclase activator represented by viliciclovir and so on, which can slow down cardiac remodeling and improve vascular function. All of the above drugs are clinical treatment options for heart failure, but it is not recommended that patients buy and take them on their own to avoid serious adverse consequences. Patients should customize their individualized treatment plan under the guidance of professional doctors in order to obtain the best therapeutic effect.