For breast cancer, whether surgery is put in front or chemotherapy is put in front, different types of breast cancer can be treated in different ways, with chemotherapy before surgery, which is neoadjuvant chemotherapy in clinical practice, that is, chemotherapy is put before surgery. For larger tumors, triple negative breast cancer, HER-2 positive breast cancer, or breast cancer with metastasis in the axillary lymph nodes, chemotherapy is often adopted before surgery. Chemotherapy first and then surgery can observe the sensitivity of the tumor to chemotherapy. If chemotherapy is effective and the tumor appears to shrink after two cycles, or 3-4 cycles, the sensitivity of chemotherapy drugs can be observed. If surgery is performed first and then chemotherapy, it is difficult to observe the sensitivity of the tumor to chemotherapy drugs. Chemotherapy first and then surgery can shrink the lesions and turn locally advanced patients into operable patients, and make patients who cannot breast conserving become breast conserving surgery through tumor shrinkage. Patients with triple negative breast cancer, patients with metastasis in axillary lymph nodes, and HER-2 positive patients can take chemotherapy before surgery, and chemotherapy before surgery is also recommended in the current clinical treatment process. However, it does not mean that the disease will be more serious if chemotherapy is given first and then surgery. The decision to take chemotherapy or surgery first for breast cancer patients is due to the specific pathological nature of the tumor and other circumstances, so chemotherapy before surgery does not mean that the disease is more serious, only that chemotherapy before surgery may be a more priority and suitable choice.