Endoscopic manifestations and clinical and pathological relationships of esophageal papilloma OBJECTIVE: To investigate the endoscopic manifestations, clinical and pathological relationships of esophageal papilloma. METHODS: Among 7320 patients who were examined endoscopically, 25 patients with endoscopic diagnosis of esophageal papilloma and 25 patients diagnosed by pathological histology; esophageal papilloma was analyzed in terms of clinical characteristics, endoscopic manifestations, pathological histology, and treatment. RESULTS: The detection rate of esophageal papilloma was 0.34% in 7320 patients, with a peak age of 41-50 years and a male-to-female ratio of 1:2.57, and the onset sites were mostly located in the middle esophagus; Hp infection was present in the stomach in 15 cases; esophageal papilloma was found again in 2 cases when gastroscopy was repeated after one year of follow-up. Esophageal papilloma appeared microscopically as a white translucent mass with a smooth surface, ranging in size from 0.3 cm × 0.4 cm to 0.8 cm × 0.8 cm; esophageal papilloma was easily treated endoscopically. Conclusion: Esophageal papilloma is a benign tumor, prevalent in women (72%), often combined with Hp infection, easily treated microscopically, and may be reinfected.