The newborn necrotizing small intestine colitis is an extremely serious disease of the neonatal digestive system, mainly in premature or sick newborns, with abdominal distension, blood in the stool as the main symptoms, characterized by necrosis of the intestinal mucosa and even the deep intestinal layer, most often occurring in the distal ileum and proximal colon. Treatment measures are as follows: 1, anti-infection should be immediately systemic application of antibiotics, according to the bacteriological examination results of the choice of antibiotics, can first choose the third generation of cephalosporin antibiotics, such as cefixime or ceftriaxone intravenous drip; or β-lactamase antibiotics and aminoglycosides, in addition should also consider the application of anti-anaerobic drugs such as clindamycin, suspected of gastrointestinal infection caused by the onset or positive blood cultures, antibiotics The choice of antibiotics should be based on the bacteria of infection, treatment must last 10 days. 2, fasting for children with possible or suspected necrotizing small intestinal colitis, should immediately fast, depending on the condition, can be fasted for 1 to 2 days, observe the development of the disease, and plan the next step of treatment; for children with confirmed diagnosis, fasting for 3 to 5 days in mild cases and 7 to 10 days in severe cases, nutrition and fluids during fasting are mainly supplemented from parenteral nutrition solution, which can be dripped from peripheral veins. Feeding can be started only when abdominal distension and vomiting disappear, appetite is restored, bowel sounds are restored, and stool occult blood test turns negative. 3.Gastrointestinal decompression is the routine measure, and a double-lumen nasogastric tube connected to a suction device is used to reduce intestinal gas accumulation. 4.Intravenous fluid supplementation and maintenance of nutrition. Children can lose a lot of fluid because of extensive intestinal inflammation and peritonitis, and need timely fluid rehydration to maintain water and electrolyte balance. Children have a long fasting period and must be rehydrated intravenously during fasting, and need total parenteral nutrition for 14 to 21 days while intestinal repair. 5, symptomatic treatment, improve microcirculation, serious illness with shock should be timely expansion treatment. The disease can occur in epidemic outbreaks and is contagious, the sick child should be isolated. The occurrence of necrotizing small bowel colitis can be reduced by delaying feeding for several days or weeks by using total parenteral nutrition for very small or sick premature infants, and then slowly increasing enteral feeding over a period of several weeks.