Right calf intermuscular vein thrombosis, which is also a type of lower extremity deep vein thrombosis, is a milder type of symptom. When right calf intermuscular vein thrombosis occurs, it should also be treated symptomatically according to the management of lower extremity vein thrombosis in the acute phase. This is due to the fact that if not treated properly, intermuscular vein thrombosis also carries the risk of dislodging the thrombus and triggering death by pulmonary embolism. Also untreated venous thrombosis can spread to the popliteal vein and even the femoral vein aggravating the existing condition. Currently, the treatment of intermuscular vein thrombosis in the lower extremities is mainly anticoagulation and decongestion therapy. Anticoagulation therapy is mainly performed by subcutaneous injection of low molecular weight heparin or oral administration of warfarin, rivaroxaban, dabigatranate, and other symptomatic anticoagulation therapy. As an adjunctive treatment, decongestion therapy is mainly performed by oral administration of horse chestnut seed extract, oral calcium hydroxybenzene sulfonate capsules, and Mizarin tablets, etc. to promote venous return and reduce tissue edema. If the treatment is standardized, most of the intermuscular venous thrombosis can be cured. If the treatment is less effective and not cured, it is recommended to have extended anticoagulation therapy and regular review of lower extremity venous ultrasound to clarify the changes of the disease.