Patient: Male, 56 years old, history of small triplet, condition shown in picture 1 (ultrasound time on 7/17/12). Ultrasound findings: 9.1CM anterior and posterior diameter of the left liver, 16.0CM oblique diameter of the right liver, 4.3*4.7CM nodular echogenicity with clear or indistinct borders in the left lobe of the liver, multiple hypoechoic nodules with 2.0*1.4CM in the right lobe of the liver. 4. splenomegaly. 5. small amount of ascites. 6. renal cysts in both kidneys. 7. no abnormal sound images of pancreas, both ureters, bladder and prostate. CT scan of the upper abdomen + enhancement Results: The liver morphology was abnormal, the ratio of each lobe was abnormal, its shape contour was not bright, multiple low-density foci were seen in the liver, the left lobe was heavy, the left lobe lesions were fused with each other, the scope was about 88MM*197MM size, after rapid injection of contrast, the lesions were not uniformly enhanced, the right lobe lesions were mainly ring-like enhancement. Tumor thrombus was seen in the left and right branches and trunk of portal vein. No enlarged lymph nodes were seen in the hilar region. The intrahepatic bile duct was normal and no stone shadow was seen in it, the gallbladder was normal in size and no stone shadow was seen in it, and the common bile duct was not dilated and no stone shadow was seen in it. The spleen was normal in size and uniform in density. The pancreas was normal in size and shape with homogeneous density. Two cysts were seen in the left kidney, the larger one was about 10 MM in diameter. Both adrenal glands were normal. Lymph nodes were seen in the hilar region and retroperitoneum, the larger one with a short diameter of about 14 MM. CT imaging diagnosis: multiple intrahepatic occupancies with a high probability of hepatocellular carcinoma. Portal vein cancer thrombosis. Enlarged lymph nodes in the hilar region and retroperitoneum. Double kidney cysts. In addition, the results of liver tumor-related antigens were: serum ferritin 1138, methemoglobin 16930, carcinoembryonic antigen 3.85, glycoconjugate antigen 19-9 was 749.1, biochemical 1+biochemical 2 test results exceeded several standards: glutamic oxalyl transaminase 96.5, glutamic oxalyl/glutamic propyl 4.23, total bile acid 10.9, alkaline phosphatase 119.7, glutamyl transpeptidase 314.2, lactate Dehydrogenase 628.5, a_lamyloglucomutase 47.8. The abnormal blood test results are: total red blood cell count 3.99, hemoglobin concentration 128.0, mean red blood cell volume 100.0, RBC volume distribution width 52.3, platelet volume distribution density 11.8. 1. I want to try to take Doxorubicin, should I do BRAF gene before taking Doxorubicin? test? 2.What are the consequences if I take Doxorubicin directly without testing? 3.Patients now have a little pain every morning without other symptoms, should I take Doximet immediately? Mei Quilin, Department of Interventional Therapy, Southern Hospital of Southern Medical University: It is not necessary to do BRAF gene test before taking Doximet. You can take the drug now. Can you upload the CT film to see if it is suitable for interventional treatment. Intervention combined with doxorubicin can improve the anti-cancer effect. Patient: Is my father’s disease suitable for CIK bioimmunotherapy? Is this treatment available in your hospital Southern Medical University Hospital Interventional Treatment Department Mei Quilin: CIK bioimmunotherapy is an adjuvant treatment method, which is not effective without the main anti-cancer treatment methods such as intervention and surgery. Specific patients themselves, if there are interventional indications use interventional combined with doxorubicin, if there are no interventional indications, use doxorubicin. Patient: I uploaded the CT film, please see if there is any good way Southern Medical University Hospital Interventional Treatment Department Mei Quilin: From the CT film, the patient’s lesion is predominantly left lobe, TACE combined with Dodgemet can be considered for treatment. Patient: Professor Mei, today my father reviewed the ultrasound and a month ago it was embolism of the left lobe branch of portal vein. Is there any treatment now? Does intervention, gamma knife, or maybe liver replacement help? We need help Mei Quilin, Department of Interventional Therapy, Southern Hospital of Southern Medical University: Portal vein trunk cancer embolism needs to be prevented from rupture and bleeding of esophagogastric fundic varices caused by portal hypertension, which has a high mortality rate. Opening portal vein through interventional method, i.e. TIPS, is one of the feasible methods to treat the disease; radiotherapy can also be considered, but there is always the possibility of rupture and bleeding of esophagogastric fundic varices before the cancer embolus shrinks and portal vein is opened. Liver replacement is not corrected.