The most effective treatment for patients with perianal abscess is the option of surgery. After surgery, anti-infective treatment should be systematically administered. Commonly used anti-inflammatory drugs include the following: first, antimicrobials of the beta-lactam class, including amoxicillin for injection, ceftriaxone for injection, meloxicillin, cefuroxime, etc. These drugs require routine drug allergy testing. Secondly, antimicrobials of macrolides, including azithromycin, roxithromycin, erythromycin, etc. Third, you can choose quinolones antimicrobials, commonly used is levofloxacin injection, you can also choose gatifloxacin injection. And for perianal abscess anti-infection treatment, you should also pay attention to local drug changes, especially after each bowel movement, should be timely cleaning and sitz bath, also pay attention to observe the exudate and healing of the wound.