Indications: Patients with advanced malignancy whose pain is not well controlled by transcatheter treatment. Spinal metastases, nerve compression, visceral pain, cancer pain syndrome. Intrathecal analgesia: A catheter is implanted in the subarachnoid space and morphine (or plus local anesthetics) is injected directly into the cerebrospinal fluid in the subarachnoid space using an internal or external drug delivery system. Morphine is 200-300 times more efficient than oral administration and has few systemic side effects; low concentrations of local anesthetics provide segmental analgesia without affecting movement and there is no or only a slight numbness in the painful area. Intrathecal drug delivery device: Advantages and disadvantages: Remote wireless analgesia system: for external analgesia pump, only $10 monthly data network cost, real-time monitoring, more secure!