The need for a puncture biopsy: Whatever the reason, when a lesion is clearly identified in the lung, liver or other parts of the body through imaging, we can speculate and suspect what kind of disease it is based on clinical manifestations, imaging and laboratory tests, but no doctor dares to be 100% sure of what kind of disease it is. For example, if a nodule is found in the lung during physical examination, different physicians will definitely diagnose it as benign or malignant, so what should be done? Anti-inflammatory treatment, or follow-up for a month or three months? If the lesion increases in size, consider it malignant and perform surgery, if there is no change in the lesion, continue observation. This is the current clinical model. If after one month or three months, the lesion increases in size or metastases appear, then the patient has lost the best time for surgery and delayed treatment. If there is no change in the lesion, can the patient be at ease? Can we just leave it alone? No, most patients must always suspect this lesion in their mind and will review it frequently. If the lesion is found at the beginning and a puncture biopsy is given, the patient will get a clear diagnosis. If it is malignant, surgery will be done first if it can be done for the best time. If surgery cannot be done, after obtaining the pathological type, relevant radiotherapy, chemotherapy and targeted drug therapy can be done (because different pathological types of tumors have different degree of sensitivity to radiotherapy and chemotherapy). The common image guidance methods for puncture biopsy are ultrasound guidance, CT guidance and magnetic resonance guidance, which have their own advantages and disadvantages. Ultrasound-guided puncture biopsy is suitable for puncture biopsy of the liver, kidney and superficial lesions. Ultrasound-guided puncture biopsy is convenient, real-time and economical, but it is difficult to display lesions in the lung and other areas; CT-guided puncture biopsy is currently the most used guidance method, with advantages such as fast CT scanning, high spatial resolution and relatively low cost, but the ionizing radiation produced by CT-guided puncture biopsy causes harm to the health of both the physician and the patient, and its soft tissue density and resolution are low. MR (magnetic resonance) guided puncture biopsy has high soft tissue resolution and high spatial resolution, and can be imaged at any angle and with multiple parameters, and there is no ionizing radiation, so the physician can always fix the puncture needle in the puncture biopsy, which greatly improves the accuracy of the puncture and reduces the complications of the puncture.