“Non-gonococcal” here refers to non-gonococcal urethritis, a kind of urethritis transmitted by sexual contact, which has the clinical manifestation of urethritis, but gonococcus cannot be detected in the urethral secretion. In addition to inflammation of the urethra, female patients may form an infection mainly in the cervical area, showing mucopurulent cervicitis. Compared with gonorrhea, non-gonococcal urethritis symptoms are milder, 70% of female patients and 30% of male patients can be asymptomatic or atypical symptoms, it is more likely to delay treatment, the formation of complications. Non-gonococcal urethritis can be cured quickly if treated in a timely manner, but if complications have developed, a longer course of treatment is needed, which increases both the economic burden and the risk of sequelae. Then, in the diagnosis and treatment of non-gonococcal urethritis should pay attention to what problems? 1, early diagnosis. If there has been a history of non-marital sexual contact in the past three months, and the urethra appears uncomfortable symptoms, or accompanied by urethral flow of abnormal secretions; female patients may also appear vulvar discomfort symptoms or abnormal vaginal secretions. With the above conditions need to go to the hospital for further examination and diagnosis, but non-gonococcal urethritis patients may be asymptomatic or atypical symptoms, therefore, the recent history of non-marital sexual contact or sexual partners with urethritis patients, should also go to the hospital for examination or counseling. 2, non-gonococcal urethritis once diagnosed, immediately full course of treatment. Early treatment can prevent complications, in addition to early interruption of the spread of the disease in the population. 3, for the last three months of sexual partners, should also be examined and treated for sexually transmitted diseases. 4, if the symptoms still persist after treatment, or symptoms disappear and then appear again, the most likely reason is that their sexual partners are untreated, re-infection occurs, or due to the presence of uncommon causes of urethritis, should be reviewed to find out the cause. 5, the standard of cure is the disappearance of the patient’s conscious symptoms, no urethral discharge, urine sediment without leukocytes. Conditional laboratory can do pathogen review.