Why do people with Parkinson’s disease experience severe dyskinesia?

  This patient, a female patient of the hospital’s DBS surgery, was only 47 years old and had Parkinson’s disease for only 5 years when she developed the very obvious anti-Parkinsonian drug-induced “anomia” and “switching phenomenon”. When there is no drug effect, he lies in bed like a plank, and his head, hands and feet do not move. When the medication was in effect, she couldn’t stop moving, especially after 1:00 p.m., and her sleep was affected by the hyperactivity, and she opted for surgery because of these conditions.  Why did she develop such serious complications after only 5 years of illness?  By understanding her medical history and medication, I think that she had a serious complication in the way she was medicated and how she was treated. I think there are big misunderstandings in her medication and her understanding of her Parkinson’s disease, and there are not a few of such patients in the clinic.  The first misconception is that she does not understand what “standardized medication” means.  This patient has taken almost all the anti-Parkinson’s drugs, such as Medopa, Benadryl, Starivol, Senfuro, Kodan, etc. He also takes medication irregularly, regardless of whether he feels poorly or has guests at home, he must take more medication, regardless of the medication interval and medication dose, as long as his state is good. This is the main reason for the emergence of isokinetic disorder, and is also the most common reason.  And do not go to the hospital by a professional doctor to judge their condition to adjust the medication, but today heard from others that this drug is effective to try, that drug is good to add. On the surface, this is because the patient does not understand the method of medication, but in fact it is a reflection of a “fear” or “dread” of the development of Parkinson’s disease, fearing that they “can not move “Therefore, they rely entirely on the information that the medication is “still in good shape” and have no control over the medication used.  Solution: Parkinson’s disease is a chronic disease, patients must be prepared for its “long-term battle”, to learn to “coexist” with Parkinson’s disease. Parkinson’s disease medication must be taken according to the patient’s condition on time and in accordance with the amount, and try to follow the “long flow of water, not to seek full effect”, in order to delay the emergence of drug side effects, to extend the control of medication time.  The second misconception is the lack of understanding of the daily health care rehabilitation of Parkinson’s patients.  The patient has been suffering from Parkinson’s disease for 5 years, and the symptoms on the left side have only been present for less than a year, with stiffness being the main symptom. I don’t know where I heard that “don’t move when there is no medication”, but as a result, every time there is no medication, he lies in bed like a plank and waits for the next medication to come, but he doesn’t move at all and doesn’t let his caregivers help him move, which is very difficult for the patient himself.  The solution: for Parkinson’s disease, the cause of the onset of certain brain functions is a kind of decline, any exercise is helpful to patients, even in the absence of drug effects, we should try to move, “with into the waste,” to mobilize their own functions in order to extend the time of functional degeneration, to maintain the ability to live.