The so-called holistic medicine is opposed to the modern mainstream Western medicine which is based on reductionism and characterized by experimental analysis, which divides and classifies the human body according to the anatomical organ system for research and clinical treatment. Human diseases do not occur and evolve according to the anatomical organ system, and according to this concept, clinicians have become “experts” in various departments, and have become railroad police – each in charge of a section. The ideological basis of holistic medicine is holistic theory, and the method is practical research method. It is to see people as a whole, and the functions of the five organs and six bowels are interconnected and mutually constrained, and any state of people is a result of the combined force of the functions of the internal organs, an outgrowth. Holistic medicine not only regards human as a whole, but also regards human as a part of nature, that is, the so-called trinity of heaven, earth and human, and the changes of natural environment affect human health and survival status, and human activities also affect the condition of nature, and the influence between nature and human is interactive. This is also the core concept of traditional Chinese medicine based on Eastern science and culture. The so-called human being is a trinity of human body, information and energy, without information only human body and energy is a plant, without energy and information is a corpse rather than a human being. The so-called functional medicine is the study of the relationship between energy and information based on the morphology of the human body, while the study of holistic medicine is not only the relationship between the human body, information and energy but also the relationship between nature and the three. The term holistic medicine has been used in ancient Greece, ancient India and ancient China. Modern holistic medicine is a new medical system based on the concept and method of complexity science, which organically combines the holistic concept of ancient traditional medicine with the empirical method of modern science. It transcends the primary stage of modern scientific development – Newtonian mechanics stage, i.e. the mainstream development mode of Western medicine based on evidence-based principles and reductionism in the simple science stage, and is the latest theory of modern scientific and cultural development – the quantum gravity stage. The future direction of medical development coincides with the latest theory of modern scientific and cultural development – quantum gravity stage.