A comparative study of Chinese and Western medicines to inhibit recurrence of pelvic endometriosis after conservative surgery
Zhao Ruihua, Hao Zengping, Zhang Yi, Meng Qingwei, Lian Fengmei, Sun Weiwei, Liu Yong, Wang Rui, et al. Zhao Ruihua, Department of Gynecology, Guang’anmen Hospital, Chinese Academy of Traditional Chinese Medicine
Abstract: METHODS: A multicenter, randomized, parallel-controlled, prospective clinical study method was used. It was conducted in eight hospitals, including Guang’anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing Hospital, Ministry of Health, Beijing Tiantan Hospital, Capital Medical University, Fuxing Hospital, Capital Medical University, Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine, and the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. All were administered within the 1st to 5th day of the first menstrual flow after conservative surgery; stage I and II patients were treated for 3 months, and stage III and IV patients were treated for 6 months. In the Chinese medicine group, Chinese herbal medicine was used for diagnosis and treatment; in the western medicine group, GnRH-a or progesterone was used. The clinical recurrence rate, pregnancy rate and incidence of adverse reactions were observed and compared between the two treatments of Chinese and western medicine. In this paper, the observation period was from 10 months to 34 months after surgery, with a mean of 20 months.
RESULTS: There was no significant difference in the clinical recurrence rate and recurrence time after conservative surgery in the two groups of pelvic endometriosis patients; the first pregnancy after conservative surgery in the Chinese medicine group was significantly earlier than that in the western medicine group (P<0.05); the incidence of adverse reactions in the western medicine group was significantly higher than that in the Chinese medicine group (P<0.01).
1 Comparison of recurrence in the two groups.
Table 1 Comparison of clinical recurrence rates after conservative surgery in patients with pelvic endometriosis in the two groups (%)
Group
N
Number of recurrence cases
Recurrence rate
X2
P
OR
95% confidence interval
RR
95% Confidence Interval
Chinese medicine group
106 cases
9 cases
8.5%
1.448
0.229
0.583
0.241 to 1.414
0.619
0.280～1.366
Western medicine group
102 cases
14 cases
13.7%