Currently the vast majority of patients with gastric ulcers can be cured with medication and do not require surgery. Drug therapy can control symptoms, promote ulcer healing, prevent recurrence and avoid complications. The most commonly used drugs in clinical practice are divided into the following categories: 1, inhibitors of gastric acid secretion: the main two types of H2 receptor antagonists and proton pump inhibitors; H2 receptor antagonists commonly used are cimetidine, ranitidine, famotidine and nizatidine; proton pump inhibitors commonly used are omeprazole, lansoprazole, rabeprazole, esomeprazole, eprazole, etc. 2.Gastric mucosal protective agent: after combined application with gastric acid secretion inhibitors, it can improve the quality of ulcer healing and reduce ulcer recurrence, commonly used are aluminum thioglycollate, colloidal bismuth, bismuth potassium citrate, misoprostol, etc. 3, gastrointestinal power drugs: mainly used for patients with nausea, vomiting, abdominal distension and other symptoms to promote gastrointestinal emptying and relieve symptoms. Commonly used are morindaine, etc. 4, eradication of H. pylori drugs: there is no single drug can effectively eradicate H. pylori, must be used in combination to improve the eradication rate of H. pylori. Commonly used are clarithromycin, amoxicillin, metronidazole (or tinidazole), tetracycline, furazolidone, certain quinolones such as levofloxacin, etc. The course of standardized treatment for gastric ulcer is usually 4-6 weeks, and some of them need to be maintained for 8 weeks. The first 2 weeks are usually for the eradication of H. pylori, followed by the continuation of consolidation therapy with drugs that inhibit gastric acid secretion and protect the gastric mucosa. Most patients with gastric ulcers are usually cured by medical treatment and do not require surgery. Surgery is required only in the following cases: ulcer haemorrhage not controlled by drugs; perforated ulcer; scarring pyloric obstruction; refractory ulcer that is not treated with drugs; ulcer with high suspicion of cancer.