Systemic lipoma belongs to multiple lipomas, which are usually small in size and often symmetrical. Lipomas located deep in the body are prone to malignant transformation and should be removed in time, and the common surgical method is superficial lumpectomy. Surface lumpectomy is a common clinical surgery, which can be done in outpatient clinic. The anesthesia is local infiltration anesthesia, commonly used 2% lidocaine infiltration anesthesia around the lipoma, followed by complete excision of the lipoma and its periphery, complete excision of the periphery can effectively prevent the recurrence of the lipoma, followed by suture closure of the incision, proper bandaging, and regular medication changes, suture removal, and then can be done. As for the lipoma in the deep part of viscera or muscle, it is necessary to incise the skin and subcutaneous tissues at the location of the lipoma until the lipoma is exposed to be excised, and sometimes it can be excised by endoscopic minimally invasive surgery.