Diabetes mellitus combined with septicemia should first be treated with antibiotics as early as possible as prescribed by the physician, and antimicrobials should be given empirically as appropriate before pathogenic results are obtained, and later the dosing regimen should be adjusted according to the species of the pathogen and the results of the drug sensitivity tests. At the same time, blood glucose should be controlled within the target range, nutritious food and sufficient fluids should be supplied, and attention should be paid to electrolyte balance and vitamin supplementation. Diabetes mellitus is a disease in which blood glucose is abnormally elevated due to impaired bioavailability of insulin in the body and insufficient insulin secretion. Sepsis is a syndrome of systemic inflammatory response caused by a definite or suspected infection. Diabetic patients with chronic poor glycemic control and low resistance may be comorbid with sepsis. When diabetes causes sepsis should apply appropriate hypoglycemic drugs according to the type of diabetes of the patient, timely control of blood glucose, and correction of metabolic disorders. Secondly, we should actively carry out anti-infective treatment, need to give sensitive antibiotics according to the results of drug sensitivity, and carry out sufficient quantity and course of anti-infective treatment. There is no cure for diabetes mellitus, but it can be controlled by five means, including patient education, self-monitoring of blood glucose, diet therapy, exercise therapy and drug therapy. If the blood sugar control is not good, you should consult a doctor in time to adjust the medication under the doctor’s guidance to control the blood sugar.