1.Lumps on any part of the body such as breast, neck or abdomen, especially if they gradually increase in size; 2.Ulcers on any part of the body such as tongue, cheek and skin without trauma, especially if they persist for a long time; 3.Unusual bleeding or discharge, such as irregular vaginal bleeding or increased discharge in women of middle age or above; 4.Dullness, burning pain, foreign body sensation behind the sternum when eating or progressive aggravation of swallowing 5.A long-standing dry cough, hoarseness or blood in sputum; 6.Long-term dyspepsia, progressive loss of appetite, and weight loss without a clear cause; 7.Change in stool habit or blood in stool; 8.Nasal congestion, epistaxis, unilateral headache or diplopia; 9.Sudden increase in size of superfluous organisms or nevus, or breakage or bleeding, or loss of original hair; 10.Painless hematuria.