If a child’s cough is more pronounced at night, it can be improved by taking the following medications. First, erythromycin or azithromycin can be given to children. At this time, children’s nocturnal cough can be considered to be caused by infection with Mycoplasma pneumoniae, which is often an irritating dry cough with (+) antibodies to Mycoplasma pneumoniae in the blood. Application of macrolide antibiotics, such as erythromycin and azithromycin later, can improve cough symptoms. Secondly, bambuterol is taken. If the nocturnal cough in children is due to cough-degenerative asthma, the application of bronchodilators can provide good relief, and bambuterol is a commonly used bronchodilator drug. Furthermore, cough due to allergic factors can also be considered and can be treated with additional anti-allergic drugs.