Most non-oncologists think that chemotherapy is a simple matter, that is, they copy the existing protocols and use them on their patients without much technical skill. Here, it is safe to say that doctors who think this way are wrong and irresponsible to their patients. In fact, due to the lack of knowledge and experience of most non-oncology specialists, chemotherapy is not standardized or even foolish. In fact, due to the lack of knowledge and experience of most non-oncologists, chemotherapy is not standardized or even haphazard. For example, many doctors in China separate the dose of oxaliplatin and give it on the 1st and 8th day, in fact, only one dose is needed because oxaliplatin has a long half-life. Foreign countries seldom use them separately, because low concentration oxaliplatin on the one hand has a weaker killing effect on tumor cells, and more annoyingly, it is easy to cause tumor cell resistance. For example, a patient with advanced pancreatic cancer with ECOG PS=0, no specific complications and a relatively young patient. In a gastroenterology department, a director gave the patient the GEMOX regimen, and the patient’s family had reminded the director if a more effective regimen could be used, which was rejected by the director. In fact, for such a patient, the FOLFIRINOX regimen was better and more efficient. For example, when a patient with advanced colon cancer came to my clinic, I asked the patient why he gave up treatment after only 2 cycles of chemotherapy (FOLFIRI), the patient replied that he was almost killed by the doctor because of the severe diarrhea caused by irinotecan, 18 days of diarrhea in the first cycle and 15 days of diarrhea in the second cycle, and he had to give up because he was dying every time. In fact, irinotecan-induced diarrhea is relatively easy to deal with, but patients with severe diarrhea are more complicated to deal with, and generally speaking, surgeons are unlikely to have the time and patience to deal with such intractable diarrhea. For example, a patient with advanced gastric cancer was not carefully evaluated before surgery and had to close the abdomen after opening it, and before closing the abdomen, a fluorouracil-like drug was injected into the abdominal cavity, and the patient’s family was told that it was advanced and inoperable. We do not talk about whether the operation is standardized and appropriate, but only about whether the drug should be administered intraperitoneally, first of all, there is no indication for this drug in the instruction manual, and what is more terrible is that the drug injected into the abdominal cavity, because the concentration is not high, but easy to cause tumor cell resistance. The above-mentioned similar situations are often encountered and need to be brought to the attention of non-oncologists.