In drug trials, azithromycin has shown no significant effect on the embryo, but there is a lack of studies in pregnant women and it is a cautionary drug. It can be used with caution under the guidance of a physician if indicated for use in pregnant women, and need not be taken orally if not indicated for use. In case of bacterial inflammation in pregnant women, cephalosporin antibiotics and penicillin can be preferred and are safer for both the pregnant woman and the fetus. If a pregnant woman is allergic to penicillin, she can choose azithromycin, which has a relatively weaker anti-inflammatory effect. If a pregnant woman has mycoplasma or chlamydia infection, azithromycin is preferred because it is more effective against mycoplasma and chlamydia, and can be taken orally in milder cases and intravenously in more severe cases. Pregnant women should pay attention to the normal liver and kidney function during the application of azithromycin and have regular pregnancy tests to check the fetal development. If azithromycin is taken for a long time, it may cause abnormal liver and kidney function and needs to be stopped in time. In addition, the common adverse reactions of azithromycin are diarrhea, nausea, abdominal pain, indigestion, vomiting, etc. Few people have dizziness, headache and allergic reactions such as fever, rash, itching, arthralgia, etc. If these manifestations are present, the drug should be discontinued in time and targeted treatment should be given.