The treatment of chronic urticaria is preferred to anti-allergic drugs, such as cetirizine, and if the effect is poor, look at the combination of ketotifen and tretinoin for oral administration. Chronic urticaria is defined as urticaria with a duration of more than 6 weeks and more than 2 episodes per week. Chronic urticaria is often related to individual constitution or chronic infection, so treatment is divided into two major blocks: controlling the condition and finding the trigger. 1, to control the condition, the first choice is the second generation of anti-H1 receptor antagonists, such as loratadine, cetirizine, imipramine, etc., choose 1-2, such as poor results, can be combined with a generation, such as paracetamol, cyproheptadine, or anti-H2 antibody antagonist ranitidine, or leukotriene receptor antagonist ketotifen. Immune modulation with compound glycyrrhizin, yuipingfeng, rehmannia, and lisinopril can also be used as appropriate. Also pay attention to the time of rash onset, if it is more in the morning, the dose should be increased before bedtime. If more before bedtime, the dose should be taken before dinner or increased. The rash is stable for 1 month after the gradual reduction of drugs. 2, looking for triggers. The common triggers of chronic urticaria are allergic constitution, chronic infection, chronic medical diseases, such as cholecystitis, gastric Helicobacter pylori infection, thyroid-related diseases, etc. Long-term treatment can be perfected with allergen examination, abdomen, thyroid ultrasound, immune function, etc. Chronic urticaria should be treated with standardized treatment, pay attention to rest in life, avoid strain, do not drink alcohol, do not eat spicy stimulation, etc.