Mastocytosis is a benign disease rather than cancer. It is caused by the increase of estrogen level in the body, which leads to the hyperplasia of the terminal ducts and alveoli of the glands and the surrounding fibrous tissue in the breast tissue, and the cuttings are accompanied by lymphocytic infiltration. Mastocytosis is divided into three types: 1, breast pain: also known as breast tissue hyperplasia, characterized by periodic pain in the breast, mostly seen in women aged 20-40, pain and menstrual cycle, premenstrual symptoms are obvious, after the relief. The correct method of examination is not to feel the lump in the breast, most of them show diffuse distribution of granular areas of local tissue thickening. Therefore, it is also called swollen granular mammary gland. Breast pain is mostly self-limiting and can be relieved after marriage and pregnancy, and no cancer will occur. 2, breast adenopathy: mostly seen in young and middle-aged women, often a limited lump in one breast with pain, or bilateral onset, pain and menstrual cycle related. The lump is small, about 1-3 cm in diameter, firm and not hard, and the boundary with the surrounding tissue is not clear. The early stage of mammary gland adenopathy is lobular hyperplasia, which is not cancerous in this fashion, but there is a 1% cancer rate in the middle and late stages of mammary gland adenopathy. 3, cystic hyperplasia of the breast: common in middle-aged women, manifested as breast lumps, but a single larger lump, round, smooth surface, cystic or solid feeling. It can also be manifested as multiple cystic nodules in the breast, and about one-third of patients can be accompanied by pain and tenderness in the early stages, but it is not significant, and sometimes there is nipple overflow. About 3-8% of male breast enlargement can become cancerous, so we should be especially vigilant and follow up regularly.