Parkinson’s patients not only have motor symptoms such as tremor, tonicity and motor slowing, but also often suffer from constipation, which can affect the quality of life in severe cases. Today I will talk to Parkinson’s patients about the science related to constipation. First of all, we need to understand the definition of constipation, it is a symptom, refers to feces in the intestine for too long, constipation, prolonged defecation cycle, or the cycle is not long, but the quality of feces dry, difficult to expel, or fecal quality is not hard, although there is the intention of the stool, but the stool is not smooth disease, need to be assisted by manipulation or medication defecation, etc.. In layman’s terms, there are five words: unpleasant bowel movement. According to the severity of constipation, often divided into three, mild refers to the symptoms of mild, does not affect life, after the general treatment can improve, without medication or a small amount of medication; severe refers to constipation symptoms persist, the patient abnormal pain, serious impact on life, can not stop medication or treatment is ineffective; moderate between the two. So, what are the hazards of constipation, including the following: (1) induce cardiovascular disease (constipation increases abdominal pressure, blood pressure, inducing angina pectoris, myocardial infarction, stroke, etc.); (2) cause hemorrhoids, anal fissures and other risks, serious rectal rupture, perforation; (3) chronic symptoms of toxicity: such as fatigue, memory loss, distraction, dizziness, insomnia, etc.; (4) increase The chance of rectal cancer. For Patients, constipation also affects the absorption of drugs, which is one of the reasons for the poor effect of drugs in some patients, and further affects the mood and quality of life of Patients. Therefore, we should pay high attention to the diagnosis and treatment of constipation. There are many factors involved in constipation, for Patients, there are three main reasons: (1) reduced activity: Patients tend to move slowly, restricted activity, or even long-term bed rest, resulting in reduced gastrointestinal motility, thus causing constipation; (2) drug factors: Patients often need to take anticholinergics, dopamine agonists, adamantine, and other anti-Parkinsonian drugs, all of which may aggravate constipation; (3) Diet and defecation habits: unreasonable eating habits, eating and drinking less water, especially too little dietary fiber; and poor defecation habits, such as irregular bowel movements, prolonged suppression of bowel movements and cause constipation. The most important concern of the people is what to do after combined constipation. First of all, we should understand that the common types of laxative drugs are divided into five categories: volumetric laxatives (bulking agents), laxative salts, osmotic laxatives, stimulant laxatives and lubricating laxatives. (1) volumetric laxatives (bulking agents) contain high-constituent cellulose derivatives, which have mild effects and are taken in large doses and are prone to gastrointestinal distention, limiting clinical use; (2) osmotic laxatives: including salt laxatives, non-absorbable sugars and polyethylene glycols, which are most commonly used clinically and are safe, such as sugar osmotic laxatives: lactulose (Dumic), which mainly acts by softening the stool, thus acting as a slow laxative, and It does not act directly on the musculoskeletal and intestinal nerves, and the laxative effect is non-toxic and non-dependent. There are also alcoholic osmotic laxatives: Fosone, Sutex, can be the first choice of drugs for the treatment of constipation. (3) stimulant laxatives: this is the most common inappropriate clinical laxative drugs, because it is stimulating the colonic mucosa, intermuscular plexus and smooth muscle, long-term use can cause severe diarrhea and abdominal pain; electrolyte disorders; drug dependence and even induce the risk of colorectal melanosis. Common medications include: Chinese medicine containing rhubarb, senna, cassia, mannitol, fruit guide tablets, aloe vera (stool pass capsule). Patients can take them for a short time, but remember not to take them for a long time. Treatment is also recommended to combine micro-ecological preparations: Methandien, Pepcid, Rectify and other drugs; gastrointestinal motility drugs: morpholine, cisapride, mosapride, etopride hydrochloride, etc.; some Chinese herbal medicines can also be chosen, such as Ma Ren Lun Gao Wan, Si Mo Tang. For specific cases, it is recommended to decide after a face-to-face consultation. Finally, we tell our patients that they should pay attention to diet and good habits. Increase the proportion of vegetables, fruits, grains and cereals intake to increase the amount of food left after digestion and absorption, stimulate intestinal peristalsis, and also retain some water and promote bowel movement. Put more vegetable oil to increase the lubrication of the intestinal tract and facilitate defecation; preferably drink 6-8 glasses of water every day to ensure that the body has enough water to moisten the intestinal soft; avoid over-eating spicy and hot diet, which is easy to consume yin and water and induce constipation. Develop a good habit of regular bowel movements: regular, concentrated, clean six words to all the pa friends. Remember to drink a glass of warm water on an empty stomach after waking up in the morning, then go to the toilet to defecate, in order to cultivate and maintain the conditioned reflex of defecation. Keep your mind happy and relaxed, and remember not to abuse laxatives.