Representative drugs of macrolide antibiotics include roxithromycin, erythromycin, azithromycin, and clarithromycin, all of which have anti-infective effects. Macrolide antibiotics are used to inhibit bacterial protein synthesis by blocking the activity of peptidyltransferase in 50S ribosomes; they are mainly used to treat gram-negative bacilli, gram-positive bacilli, anaerobic bacilli, mycoplasma, and chlamydia infections; they can be used for treating respiratory infections, soft-tissue infections of the skin and mycoplasma pneumonia, and so on. The side effects of macrolide antibiotics are: ① gastrointestinal irritation, such as nausea, vomiting, abdominal pain, etc.; ② liver function is impaired, such as transaminase abnormalities, etc.; ③ cardiotoxicity, such as arrhythmia, palpitations, etc.; ④ ototoxicity, such as damage to the cochlear nerve, deafness and so on. When taking these macrolide antibiotics for treatment, you need to take them under the guidance of a doctor, not private medication, in addition, allergic to macrolide antibiotics are prohibited to avoid serious adverse reactions.