The bottom of the foot has a honeycomb of small holes to consider is due to metatarsal warts, tinea pedis or fossa keratosis pilaris caused by. 1. metatarsal warts: metatarsal warts is due to human papilloma virus infection caused by the metatarsal skin proliferation, in the early stage of the disease for small, shiny papules, with the development of the disease will gradually increase to soybean size, sometimes several metatarsal warts gathered together, but also formed a number of keratosis pilaris, presenting a honeycomb hole lesion state. 2. Tinea pedis: Tinea pedis is a fungal infection of the foot caused by fungi, mainly manifested in groups or scattered distribution of small blisters, if the gathering of small blisters after drying and absorption will appear honeycomb small holes, so the soles of the feet have honeycomb small holes to consider may be due to tinea pedis. 3. Foveal keratolysis: Foveal keratolysis is a bacterial skin infection of the feet, mainly characterized by crater-like pits on the soles of the feet, so the soles of the feet with honeycomb-like lesions may also be due to foveal keratolysis. As there are many factors that can cause honeycomb holes on the soles of the feet, it is recommended to go to the hospital for examination and diagnosis when symptoms occur, so that the cause can be identified as soon as possible and active targeted treatment can be taken to avoid worsening of the symptoms.