Pulmonary nodules are a common clinical sign, mostly referring to round-like or irregular-shaped lesions with diameter ≤3cm in the lung, which can be single or multiple, with clear or unclear borders. Usually the symptoms are not obvious, but if symptoms such as persistent cough, frequent dyspnea and persistent chest pain occur, patients need to be highly alert to whether the lung nodules have signs of cancer: 1. Persistent cough: Patients with lung nodules usually have irritating dry cough without sputum or little sputum, and when patients have aggravated cough, persistent high-pitched heavy metallic sounding cough or irritating choking cough, they need to be alert to the possible malignant transformation of lung nodules. Compression of the bronchus by the lesion may lead to airway narrowing and the above symptoms; 2. Frequent dyspnea: If the patient feels that he/she has insufficient air and struggles to breathe, he/she objectively shows that the respiratory movement is hard, and in severe cases, there may be symptoms such as open-mouth breathing, nasal flapping, telescopic breathing, or even cyanosis, and accompanied by changes in respiratory frequency, depth, and rhythm. If the above symptoms appear, we need to be alert to the enlargement of the nodule, compressing the large bronchus, leading to the patient’s dyspnea; 3, persistent chest pain: if the patient has persistent hidden pain in the chest, the pain site is fixed, mainly in the shoulder, axilla, radiating to the inner side of the upper limbs and other symptoms, there may be malignant lung nodules, metastasis or direct invasion of the pleura and chest wall, which can lead to the above situation. In addition, coughing or breathing, etc. may also aggravate the symptoms of chest pain. In addition to the above, if patients have blood in sputum or hemoptysis, they need to be alert to the occurrence of central lung cancer, which may lead to intermittent or persistent blood in sputum due to the growth of tumor into the lumen, and may cause hemoptysis if the surface of the lumen is severely eroded and erodes large blood vessels. When the above symptoms occur, you should seek medical attention and take appropriate treatment measures.